When the Fight against Fungi Goes Wrong

When the Fight against Fungi Goes Wrong

When the Fight against Fungi Goes Wrong

Fungi are associated with a wide spectrum of diseases in humans, with increasing morbidity and mortality [1]. Therefore, it is of great importance to elucidate the genetic and immunological mechanisms underlying the susceptibility to fungal infections. Recent studies of primary immunodeficiencies (PIDs)—a group of hereditary immune disorders with increased susceptibility to infection—have led t...

When the Swiss clock goes wrong

A Swiss clock and entry into mitosis have something in common: both must be very precise. When the Swiss clock goes wrong, the consequence is the loss of reputation. When entry into mitosis goes wrong, cells may divide in an aberrant way. More generally, cell division events are tightly regulated at the temporal and spatial levels. We have recently shown that in C. elegans, misregulation of the...

NetReview: Detecting When Interdomain Routing Goes Wrong

Despite many attempts to fix it, the Internet’s interdomain routing system remains vulnerable to configuration errors, buggy software, flaky equipment, protocol oscillation, and intentional attacks. Unlike most existing solutions that prevent specific routing problems, our approach is to detect problems automatically and to identify the offending party. Fault detection is effective for a larger...

When Emotion Goes Wrong : Realizing the Promise of Affective Science

In his Nicomachean Ethics, Aristotle argued that emotions are adaptive when they are about the right things, are expressed in the right way, arise at the right time, and last the right amount of time. By contrast, emotions are maladaptive when they are about the wrong things, are expressed in the wrong way, arise at the wrong time, or are the wrong duration. This analysis led Aristotle to recom...